PRODUCT DETAILS

About Depnsaid SP 50 mg/500 mg/10 mg Tablet

DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE belongs to the class of combination medication called NSAIDs (non-steroidal anti-inflammatory drugs) used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis. Besides this, it also helps treat muscle pain, tooth pain during dental surgery, menstrual period pain/cramps, ear pain, and migraine headaches. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Arthritis is the tenderness and swelling in the joints which causes pain and joint stiffness.

DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE is a combination of three drugs, namely: Diclofenac, Paracetamol, and Serratiopeptidase. Diclofenac and Paracetamol work by blocking the effect of a chemical messenger, known as cyclo-oxygenase (COX) enzymes that make other chemical prostaglandins (PG). These prostaglandins are produced at injury sites and cause pain, swelling, and fever. By blocking the COX enzyme's effect, lesser PGs are produced, which reduces mild to moderate pain, inflammation, and fever. On the other hand, Serratiopeptidase is a bacterial protein enzyme found in the silkworm which acts as a mucolytic (dissolves thick protein at the injured/affected site) and anti-inflammatory agent thereby decreasing swelling at the painful site. 
 
Take DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE with or without food. Swallow DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE as a whole with a glass of water, do not chew or break the tablet. You are advised to take DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE for as long as your doctor has prescribed it for you. Depending on your medical condition, you may experience certain common side-effects such as nausea, vomiting, stomach pain, headache, indigestion, and diarrhea in some cases. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE can increase your risk of fatal heart attack or stroke. So, if you have had any recent heart surgery, do not take DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE. DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE increases the chances of stomach ulcers and bleeding. Do not take DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE if you are pregnant or breastfeeding unless prescribed. DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE causes drowsiness and dizziness, so drive with caution. DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol along with DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE as it could lead to increased drowsiness and dizziness; it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Depnsaid SP 50 mg/500 mg/10 mg Tablet

Pain and Inflammation are associated with osteoarthritis, muscle pain, joint pain, rheumatoid arthritis, mild migraine, dental pain, etc.

Medicinal Benefits of Depnsaid SP 50 mg/500 mg/10 mg Tablet

DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE is a combination of three drugs, namely: Diclofenac (pain killer), Paracetamol (fever reducer), and Serratiopeptidase (protein enzyme). DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE is a combination medicine used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, muscle pain, tooth pain, bone and joint pain, headache, swelling, period pain, ear pain, migraine, fever,  sore throat, nose pain, etc. DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE increases the pain threshold and blood flow across the skin. Diclofenac and Paracetamol work by blocking the effect of a chemical messenger known as cyclo-oxygenase (COX) enzymes that make other chemical prostaglandins (PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the COX enzyme's effect, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Serratiopeptidase breaks down the abnormal proteins at the site of inflammation, thereby reducing inflammation. 

Directions for Use

Take DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE with food. Swallow DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE as a whole with a glass of water; do not chew, or break the tablet. Based on your medical condition, your doctor will decide how long you need to take DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE.

Side Effects of Depnsaid SP 50 mg/500 mg/10 mg Tablet

• Nausea
• Vomiting
• Stomach pain
• Diarrhea
• Indigestion
• Headache

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

Do not take DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE if you are allergic to paracetamol, diclofenac, or serratiopeptidase, have/had severe heart problems, stomach ulcer, or perforation, bleeding problems such as bleeding from the stomach, intestine or brain, have undergone any heart bypass surgery, have had any heart attack, blood circulation problems or inflammation of intestines. DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE can increase your risk of fatal heart attack or stroke so, if you have had any recent heart surgery, do not take DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE. Avoid using DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE if you are pregnant, planning for pregnancy, or breastfeeding unless prescribed. DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE may cause drowsiness and dizziness, so drive only if you are alert. DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE is not recommended for children less than 10 years of age as the safety and effectiveness have not been established. Avoid consuming alcohol and DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE as it could lead to increased drowsiness and increase the risk of stomach bleeding. Stop taking DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach such as blood in stools. Do not take any other NSAIDs for pain relief along with DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE unless prescribed. 

Drug Interactions

Drug-Drug Interaction:

DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE may have interaction with pain killers (aspirin, ibuprofen), immunosuppressant (cyclosporine, tacrolimus), anti-psychotic (lithium), cardiac glycoside (digoxin), blood thinner (warfarin), anti-rheumatoid (methotrexate), antacid (magnesium hydroxide), anti-fungal (ketoconazole, miconazole, fluconazole, voriconazole), anti-arrhythmic (amiodarone), anti-gout (sulphinpyrazole), anti-emetic (metoclopramide, domperidone), bile acid sequestrant (cholestyramine), anti-cancer (imatinib), antibiotic (chloramphenicol), anti-progestational steroid (mifepristone), anti-diabetics, diuretics, anti-hypertensives medicines.

Drug-Disease Interaction:

DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE may have interactions with stomach ulcer or perforation, bleeding problems, bypass surgery, heart attack, blood circulation problems, inflammation of intestines, anemia, heart, kidney, and liver problems.

Safety Advice

ALCOHOL

Avoid consumption of alcohol while taking DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE as it may increase drowsiness. It can also increase the risk of stomach bleeding.

PREGNANCY

Avoid taking DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE if you are pregnant unless prescribed by a doctor. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

BREAST FEEDING

Consult your doctor before taking DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE; your doctor will decide whether DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE can be taken by breastfeeding mothers or not.

DRIVING

DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE may cause dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

LIVER

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

KIDNEY

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.